1-(substd phenyl)biguanides - for treating gastric ulcers and spasms and hypertension and as minor tranquillizers

摘要

Cpds. of formula: (I) A is phenyl subs. by (R)n, Hal, Alk, (II) A is phenyl subst. by X, Y, Z and (III) A is phenyl subst. by Y', X' and medicaments contg. them and medicaments cotng. cpds. (IV) (where n is 1-3, Alk, Hal, and R are in any position, alk is 1-7C-alky or alkenyl, Hal is F, Cl, Br or I, R is H, F, Cl, Br or I, provided Alk is not 2-Me when Hal is Cl or 4-Br and R is H or when Hal and R are 3,5-di-Cl and also provided Alk is not 4-Me or 4-Bu when Hal is 3-Cl and R is H, X, Y and Z may be in any position, provided one of X and Y is not 2-Br when the other is 4-Cl or 4-Br and Z is H, and also when X and Y are other than 2,6-Cl Z is other than H and further provided than when X, Y and Z are Cl and X and Y are in the 3 and 4 positions, Z is always in the 2 position, X' is 2-CF3 when Y is halo, NO2 or CF3 or X' is 3-CF3 when Y' is halo, NO2 or CF3 provided Y' is other than 4-halo or 4-NO2 or X' is 4-CF3, when Y' is NO2 or CF3 and X' is H when Y' is CF3O, F2CH CO, F3CCO or F3SO2, and R2-R6 are H, alkyl, alkenyl, halo, NO2, NH2 (Alkyl)2N, haloalkyl, haloalkoxy, haloalkanoyl, OH, CN, NCS, COOH, COOALkyl, (Alkyl)2 NSO2, Alkyl SO2, HaloalkylSO2, PhO acyloxy, halophenoxy, Ph or halophenyl) are prepd, by reacting an aniline with a cyanoguanidine or by alkylating, halogenating, nitrating etc. an unsubstd 1-phenyl biguanido and if required prepg unit dosage forms for oral or parenteral administration.