Pyranobenzoxadiazole derivatives, a pharmaceutical preparation which comprises them, and processes for preparing the derivatives

摘要

The invention includes compounds of the formula (I): wherein A represents OH or OC(O)CH3-nXn, B represents hydrogen atom, or A and B together represent a bond; R<1> represents hydrogen atom, R<2> represents hydrogen atom, C(Z)CH3-nXn or C(Z)NHCH3-nXn or R<1> and R<2> together represents (CH2)m, (CH2)m-1C(Z), N(R<3>)(CH2)2C(Z), (CH2)m-2NHC(Z) or (CH2)m-2OC(Z) in which X represents fluorine atom, chlorine atom, bromine atom, a methyl group or a methoxy group and n represents 0 or an integer of 1 to 3, Z represents oxygen atom or sulfur atom, m represents an integer of 4 or 5 and R<3> represents hydrogen atom or a methyl group, and pharmacological acceptable salts of the compounds which can form salts, preparation methods therefor, pharmaceutical use of the compounds and compositions comprising the compounds.