NACHWEIS DES MENSCHLICHEN TUMORFORTSCHRITTES UND HEILMITTELWIDERSTANDES

摘要

Changes in tumor cell RNA and DNA are utilized to detect the progression and the temporal changes in resistance to chemotherapy in human tumors. The present invention provides a method for determining whether human cancer cells are sensitive or resistant to a particular drug, to allow for early detection of drug resistance in order to improve significantly the efficiency of a cancer chemotherapy protocol. The method involves the detection of DNA sequences indicative of drug resistance.