| 发明名称 |
SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
| 摘要 |
The present invention is directed to spiro-substituted azacycles of formula (I) (wherein R1, 1, m, Q, W, X, Y and Z are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
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| 申请公布号 |
WO9825605(A1) |
申请公布日期 |
1998.06.18 |
| 申请号 |
WO1997US23586 |
申请日期 |
1997.12.12 |
| 申请人 |
MERCK & CO., INC.;MILLS, SANDER, G.;SPRINGER, MARTIN, S.;MACCOSS, MALCOLM |
发明人 |
MILLS, SANDER, G.;SPRINGER, MARTIN, S.;MACCOSS, MALCOLM |
| 分类号 |
A61K31/438;A61K31/444;A61K31/4747;C07D471/10;C07D491/10;C07D495/10;(IPC1-7):A61K31/33;A61K31/395;A61K31/41;A61K31/435;A61K31/55;C07D513/10 |
主分类号 |
A61K31/438 |
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