Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.
申请公布号
WO2006029010(A3)
申请公布日期
2006.09.08
申请号
WO2005US31407
申请日期
2005.09.02
申请人
THE UNIVERSITY OF CHICAGO;THE SCRIPPS RESEARCH INSTITUTE;BRIGHAM YOUNG UNIVERSITY;BENDELAC, ALBERT;ZHOU, DAPENG;TEYTON, LUC;SAVAGE, PAUL
发明人
BENDELAC, ALBERT;ZHOU, DAPENG;TEYTON, LUC;SAVAGE, PAUL