COMPOSITIONS AND METHODS FOR TREATMENT OF CERVICAL CANCER

摘要

the present invention provides a recombinant Listeria strain, comprising a first peptide fused to an Human Papilloma Virus (HPV) E7 antigen, wherein said first peptide is selected from (a) an N-terminal fragment of an LLO protein; (b) an ActA protein or N- terminal fragment thereof; and (c) a PEST-like sequence-containing peptide for uses related to treating and protecting against cervical cancer. The present invention also provides use of the recombinant Listeria strain in methods for inducing an anti-E7 CTL response in a human subject and for treating HPV-mediated diseases, disorders, and symptoms.