| 发明名称 |
TRPM4 CHANNEL INHIBITORS FOR STROKE TREATMENT |
| 摘要 |
The present invention relates to methods for treating ischemic stroke including extension of the therapeutic time window for reperfusion. More particularly, the invention relates to a method of treating stroke in a subject by inhibiting the transient receptor potential melastatin 4 (TRPM4) channel. The present invention also provides uses of TRPM4 inhibitors, TRPM4 antibodies and kits for use in the methods of the invention. |
| 申请公布号 |
US2016168245(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201414392213 |
申请日期 |
2014.06.30 |
| 申请人 |
SINGAPORE HEALTH SERVICES PTE LTD |
发明人 |
Liao Ping;Loh Kok Poh |
| 分类号 |
C07K16/28;A61K31/713;A61K45/06;A61K39/395;C12N15/113 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody or fragment thereof specific to the transient receptor potential melastatin 4 (TRPM4) protein, wherein the antibody specifically binds to a peptide sequence which lies between S5 and the P-loop of the TRPM4 protein and inhibits TRPM4 activity. |
| 地址 |
Singapore SG |
