| 摘要 |
PROBLEM TO BE SOLVED: To provide humanized antibodies targeting the EC1 domain of cadherin-11 and related compositions and methods.SOLUTION: Provided is a humanized antibody that specifically binds an EC 1 domain of a mammalian Cadherin-11 protein and antagonizes the mammalian Cadherin-11 protein, comprising an antibody variable heavy chain region comprising an amino acid sequence selected from the group consisting of SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67 and SEQ ID NO:69.SELECTED DRAWING: None |
