HUMAN CANCER-RELATED GENE, ITS ENCODED PRODUCTS AND APPLICATIONS

摘要

The invention discloses a human cancer-related gene, LAPTM4B, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the following nucleotide sequences: (1) SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 6, or SEQ ID No: 8 in the sequence listings; (2) Polynucleotides that encode the protein sequences of SEQ ID No: 4, SEQ ID No: 5, or SEQ ID No: 7 in the sequence listings; (3) DNA sequences having above 90% homology with the DNA sequences specified by SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 6, or SEQ ID No: 8 in the sequence listings, and these DNA sequences encode the proteins with the same or similar functions. This invention enables the developments of new anti-cancer approaches and new anti-cancer medicines. It would create a significant impact on human society.

主权项

1. An in vitro method of detecting cancer or risk of cancer in a human patient, comprising detecting up-regulation of an LAPTM4B protein comprising the amino acid sequence of SEQ ID No: 4 in comparison with the level of said protein in paired non-cancerous and normal tissue, wherein the cancer is hepatocellular carcinoma, stomach cancer, breast cancer, lung cancer or prostate cancer.