Transition metal complexes for enantioselective catalysis of carbon-carbon, carbon-heteroatom, and carbon-hydrogen bond forming reactions

摘要

In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula Φ-[M(x,y)-L1(w,v)-L2(t,u)-L3]p+An−mZ−p_m. In an embodiment of the present disclosure Φ may be A. In another embodiment Φ may be Δ. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L1, L2, and L3 independently is a ligand comprising a substituted diamine. In some embodiments, An″ comprises a lipophilic anion, where m is from 1 to 3, and where Z− comprises an optional second anion.

主权项

1. A catalyst, comprising a transition metal complex having the formula Φ-[M(x,y)-L1(w,v)-L2(t,u)-L3]p+An−mZ−p-m, wherein Φ is Λ or Δ, wherein M is a transition metal, wherein p is an integer corresponding to the oxidation state of M, wherein each of x, y, w, v, t, and u independently comprises one of R and S, wherein each of L1, L2, and L3 independently is a ligand comprising a substituted diamine, wherein An− comprises a lipophilic anion, wherein m is from 1 to 3, wherein Z− comprises an optional second anion, and wherein the catalyst has an enantioselectivity of at least 60% for one or more of a carbon-carbon bond forming reaction, a carbon-heteroatom bond forming reaction, and a carbon-hydrogen bond forming reaction.