New tetralone derivs. - used for treating e.g. hypertension, asthma, angina, congestive heart failure, epilepsy, irritable bowel syndrome and incontinence

摘要

Tetralones of formula (I) and their salts are new. In (I) R1 and R2 are H, alkyl, hydroxy, alkoxy, formyl, alkylcarbonyl, alkylthiocarbonyl, carboxyl, alkoxycarbonyl, alkoxythiocarbonyl, alkylcarbonyloxy, alkylthiocarbonyloxy, hydroxyalkyl, mercaptoalkyl, perfluoroalkyl, nitro, amino, cyano, halo, trifluoromethoxy, ethynyl, etc.; R3 is H or alkyl; R4 is alkyl; or R3 + R4 are 2-5C polymethylene; alkyl is 1-4C alkyl; R5 is hydroxy, acetoxy or formyloxy; R6 is H; or R5 + R6 is a bond; Z is O or NR8; R7 is a gp. R9 when Z is O; or a radical R9 or C(=X)R10 when Z = NR8; R8 is H, 1-6C alkyl, 1-6C alkoxy, aryloxy, arylmethyloxy, 1-6C alkoxycarbonyloxy, arylcarbonyloxy, 1-6C alkylcarbonylamino or aryl carbonylamino; X is O, S or NCN; R9 is 3-6C cycloalkyl, 3-6C cycloalkenyl, phenyl or heteroaryl, all opt. substd. by 1 or 2 halo and/or 1-6C alkyl, 2-4C alkenylmethyl, 2-4C alkynylmethyl or R11; R10 is H, 1-6C alkyl opt. substd. by hydroxy, 1-6C alkoxy or 1-6C alkoxycarbonyl, 2-6C alkenyl, 3-6C cycloalkyl, 3-6C cycloalkenyl, and phenyl or heteroaryl opt. substd. by halo, 1-6C alkyl or R11; and R11 is 1-6C alkoxy, thioalkoxy, alkylcarbonyloxy, alkylcarbonyl, alkylthiocarbonyl or alkoxycarbonyl, hydroxy, oxo, nitro, cyano, trifluoromethyl, carboxyl, mercapto, amino (opt. substd. by 1 or 2 1-4C alkyl or aryl).