发明名称 |
METHOD OF CLEAVING SPECIFIC STRANDS OF RNA |
摘要 |
A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase. |
申请公布号 |
WO9409129(A3) |
申请公布日期 |
1994.05.26 |
申请号 |
WO1993US10103 |
申请日期 |
1993.10.20 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS;THE CLEVELAND CLINIC RESEARCH INSTITUTE |
发明人 |
TORRENCE, PAUL;SILVERMAN, ROBERT;MAITRA, RATAN;LESIAK, KRYSTYNA |
分类号 |
C12N15/09;C07H21/00;C07H21/02;C12N9/16;C12N15/113 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|