摘要 |
1,214,357. 9,10-Ethanoanthracene derivatives. MERCK & CO. Inc. 18 March, 1968 [21 March, 19671, No. 62407/69. Divided out of 1,214,356. Heading C2C. The invention comprises compounds of the Formula I, wherein R represents an alkanoyl group or a ketalized derivative thereof, each of R<SP>3</SP> and R<SP>4</SP> represents a hydrogen or halogen atom or an alkyl, alkoxy, or trifluoromethyl group and X represents an amino, alkoxycarbonylamino, cyano, carboxy or alkoxycarbonyl group, except that X is not amino when R is ketalized alkanoyl and their preparation by reacting a 9-alkanoylanthracene of the Formula II where R‹ represents an alkanoyl group with acrylic acid, an alkyl acrylate or acrylonitrile to form a 9-alkanoyl-9,10-ethano- 11-(carboxy, alkoxycarbonyl, or cyano)dihydroanthracene of the Formula III wherein X<SP>1</SP> represents a carboxy, alkoxycarbonyl or cyano group and optionally ketalizing the product or by reacting a compound of the Formula IV with hydrozoic acid to convert the carboxylic group to a primary amino group or by reacting an ester of the Formula V with hydrazine, treating the resulting hydrazide with nitrous acid to form a urethane of the Formula VI and hydrolysing the latter to produce a compound of the Formula VI. |