发明名称 |
BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES |
摘要 |
The subject of the invention is compounds of general formula (I), in which: X represents O or CHR; R1, R2, R3 and R4, which are identical or different, represent a hydrogen atom or a C1-C7 alkyl group, it being possible for R1 to additionally form a bond with R; R5 represents a hydrogen atom, a hydroxyl group or R5, taken together with R7, forms a bond or a <SIGN> O group; R6 represents a group of formula (a) in which R10 and R11, taken together with the carbon atom to which they are attached, form a nitrogenous heterocyclic group, and their N-oxides and pharmaceutically acceptable salts. These compounds are powerful activators of potassium channels. |
申请公布号 |
WO9413658(A2) |
申请公布日期 |
1994.06.23 |
申请号 |
WO1993EP03445 |
申请日期 |
1993.12.07 |
申请人 |
MERCK PATENT GMBH;BERTHELON, JEAN-JACQUES;BRUNET, MICHEL;NOBLET, MARC;DURBIN, PHILIPPE;GUERRIER, DANIEL;LUONG, TRONG, NGHIA |
发明人 |
BERTHELON, JEAN-JACQUES;BRUNET, MICHEL;NOBLET, MARC;DURBIN, PHILIPPE;GUERRIER, DANIEL;LUONG, TRONG, NGHIA |
分类号 |
C07D215/14;A61K31/355;A61K31/55;A61P9/08;A61P9/10;A61P11/00;A61P11/08;A61P17/00;A61P21/02;A61P25/02;C07C57/30;C07C59/68;C07D213/24;C07D213/30;C07D213/57;C07D213/60;C07D213/89;C07D313/08;C07D405/04;C07D409/04;C07D493/04 |
主分类号 |
C07D215/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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