1,3-dihydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepine-2-one - diaminoacetate esters - cns depressants

摘要

Title cpds. are of formula (I): (where R1 is 1-6C alkyl opt. substd. by 6-10C aryl; R2 is ANR6R7 where A is 1-6C alkylene and R6 and R7 are 1-6C alkyl opt. substd. by 6-10C aryl, or NR1R2 = R4 is 1-6C alkyl opt. substd. by 1-6C O-alkyl, OH or 6-10C aryl, or 6-10C aryl, R5 is 1-6C NH alkyl or piperidino; n is 3-5; m is 1 or 2; r is 2 or 3; s is 0-6; t is 0-6; s+t = 3-6; R3 is H, 1-6C alkyl opt. substd. by 1-6C Oalkyl or 6-10C aryl; X is hal, CN, CF3, NO2 or 1-6C S-alkyl; and Y is H, hal, CF3, NO2, or 1-6C S-alkyl) and salts of (I). (I) are prepd. by reacting a 3-haloacetate ester with 2-3 moles of an amine HNR1R2.