Psychotropic piperidinespiro-oxazines and-oxazolidines

摘要

Psychotropic piperidine spiro-oxazines and oxazolidines. Compounds of formula (I) and their acid addition salts (where Z is a group of formula (II) or (III); R is H, F, Cl, methyl, methoxy, acetyl or trifluoromethyl; R1 and R2 are H, 1-4C alkyl or phenyl; R3 is H or 1-4C alkyl; A is 1-4C alkylene; X is S, ethylene, vinylene or isopropylidene; n is 0 or 1), suppress motility, lower body temperature and potentialise reserpine. They are psychotropic agents for the treatment of schizophrenia, manic-depressive psychosis, neurosis and psychosomatic diseases.