| 摘要 |
PURPOSE:To obtain an easily formulable and biodegradable sustained release composite having moderate biodegradability and purifying characteristics of the polyactic acid and moderate sustained release characteristics of a physiologically active substance, by using a specific low-molecular weight polylactic acid as a carrier for the physiologically active substance. CONSTITUTION:An easily formulable and biodegradable sustained release composite obtained by entrapping a physiologically active substance in polylactic acid having 200-10,000 molecular weight as a carrier having a relatively high biodegradation rate, capable of completing the degradation in a desired period and promoting the release of the physiologically active substance regardless of the water solubility thereof, and easily formulable by softening and melting the above-mentioned carrier under a suitable pressure at a suitable temperature, and having sustained release function of the physiologically active substance. The above-mentioned composite is obtained by treating a mechanical mixture of the physiologically active substance with the above-mentioned carrier under ordinary pressure -1,000kg/cm<2> at ordinary temperature -150 deg.C while heating under pressure to soften and melt at least the above-mentioned carrier and molding the mixture in to a desired shape.
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