PROGRAMMED CELL DEATH AND INTERLEUKIN-1 beta

摘要

Methods for modulating programmed cell death are provided. Apoptosis, induced by a variety of stimuli, can be inhibited by blocking IL-1 beta binding to its type-1 receptor. Additionally, IL-1 beta had anti-apoptotic activity when added exogenously prior to exposure to apoptotic stimuli. ICE cleavage of pro-IL-1 beta is an important step in apoptosis, and mature IL-1 beta may function as a positive or negative mediator of cell death.