发明名称 |
SULFONEAMIDE INHIBITORS OF HIV-ASPARTYLPROTEASE, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, METHOD OF INHIBITOR IDENTIFICATION |
摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a new class of sulfoneamides of the formula (I) that are inhibitors of aspartylprotease. Invention relates also to a new class of HIV-aspartylprotease inhibitors exhibiting specific structural and physico-chemical properties. Invention relates to also pharmaceutical compositions containing these compounds. Compounds and pharmaceutical compositions are suitable especially for inhibition of HIV-1 and HIV-2 protease activity and they can be used as effective antiviral agents against HIV-1 and HIV-2 viruses. The present invention relates also to methods of inhibition of activity of HIV-aspartylprotease by using compounds of the present invention and methods of screening compounds by their anti-HIV activity. EFFECT: enhanced effectiveness of sulfoneamide inhibitors. 26 cl, 3 dwg, 8 tbl, 197 ex
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申请公布号 |
RU2135496(C1) |
申请公布日期 |
1999.08.27 |
申请号 |
RU19950109928 |
申请日期 |
1993.09.07 |
申请人 |
VERTEKS FARMAS'JUTIKALZ INKORPOREJTED |
发明人 |
RODZHER D.TANG;MARK A.MARKO;GOVINDA RAO BKHISETTI |
分类号 |
G01N33/53;A61K31/16;A61K31/165;A61K31/17;A61K31/18;A61K31/255;A61K31/27;A61K31/325;A61K31/34;A61K31/341;A61K31/343;A61K31/35;A61K31/40;A61K31/4015;A61K31/403;A61K31/404;A61K31/41;A61K31/415;A61K31/42;A61K31/421;A61K31/4245;A61K31/425;A61K31/426;A61K31/44;A61K31/4402;A61K31/4418;A61K31/4433;A61K31/445;A61K31/47;A61K31/495;A61K31/496;A61K31/505;A61K31/535;A61K31/5375;A61K31/5377;A61K31/63;A61K38/00;A61K38/55;A61P31/12;A61P31/18;C07C307/02;C07C307/06;C07C311/13;C07C311/18;C07C311/29;C07C311/39;C07C311/41;C07C311/46;C07D207/12;C07D207/26;C07D207/27;C07D207/28;C07D209/08;C07D209/10;C07D213/30;C07D215/48;C07D231/14;C07D239/22;C07D239/54;C07D263/24;C07D271/08;C07D277/20;C07D277/36;C07D295/12;C07D305/12;C07D307/12;C07D307/14;C07D307/20;C07D307/52;C07D307/64;C07D307/79;C07D403/12;C07D405/12;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D419/14;C07G99/00;C07K5/078;G01N33/569;(IPC1-7):C07D413/12 |
主分类号 |
G01N33/53 |
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