| 发明名称 |
Photosensitizer and method for production thereof |
| 摘要 |
The invention relates to medicine and concerns a photosensitizer for detecting and curing tumors. The inventive photosensitizer is embodied in the form of a composition containing chlorin in the form of salt and alkali metals. The chlorin is composed of 80-90% of chlorin e<SUB>6</SUB>, 5-20 of purpurin 5 and the rest being purpurin 18 -chlorin p<SUB>6</SUB>. Said photosensitizer is produced by extracting Spirulina biomass with the aid of acetone. Afterwards said biomass is exposed to acid treatment, neutralization, hydrolysis, extraction of pheophorbide a, dissolution in acetone, addition of a strong base, neutralization and reprecipitation of chlorin e<SUB>6</SUB>.
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| 申请公布号 |
US6969765(B2) |
申请公布日期 |
2005.11.29 |
| 申请号 |
US20040473445 |
申请日期 |
2004.03.15 |
| 申请人 |
OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIJU "RADA-PHARMA" |
发明人 |
RESHETNIKOV ANDREI VALENTINOVICH;ZALEVSKY IGOR DMITRIEVICH;KEMOV JURY VIKTOROVICH;IVANOV ANDREI VALENTINOVICH;KARMENYAN ARTASHES VACHEEVICH;GRADJUSHKO ALEXANDR TIKHONOVICH;LAPTEV VLADIMIR PETROVICH;NEUGODOVA NATALIYA PETROVNA;ABAKUMOVA OLGA YURIEVNA;PRIVALOV VALERY ALEXEEVICH;LAPPA ALEXANDR VLADIMIROVICH;ROMANOV VLADIMIR ALEXANDROVICH |
| 分类号 |
A61K31/409;A61K41/00;A61K49/00;A61P35/00;C07D487/22;(IPC1-7):A61K31/66;A61K31/555;A61K31/40;A61K38/00;C07F5/00 |
主分类号 |
A61K31/409 |
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