POROUS COLLAGEN-HYALURONIC ACID COMPLEX MATERIAL AND METHOD FOR THE PREPARATION THEREOF

摘要

A porous collagen-hyaluronic acid composite material and a manufacturing method thereof are provided to minimize rejection in transplanting the composite material, to secure excellent mechanical property and tissue compatibility, and to make a manufacturing process simple. A porous collagen-hyaluronic acid composite material is produced by forming an aggregate by mixing collagen and hyaluronic acid at pH of 3.0~5.0 and then lyophilizing the aggregate. Atelo collagen or soluble collagen is used. The hyaluronic acid has the molecular weight of 800,000~200,000,000 Daltons. The collagen and hyaluronic acid are mixed at the volume rate of 1:1~2:1. GAG(Glucosaminoglycan) is added at the rate of 1:0.1~1:0.5 for the hyaluronic acid. The GAG is selected from a group comprising chondroitin, chondroitin sulphate, heparin, and heparin sulfate.