PHARMACEUTICAL FORM WITH IMPEDED ABUSE

摘要

The present invention relates to a multiparticulate pharmaceutical form with impeded abuse including at least one active ingredient with the potential for abuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic, or synthetic wax (D), at least one agent promoting breakdown (E), and optionally one or more additional physiologically tolerable excipients (B), wherein the individual particles of the pharmaceutical form have a breaking strength of at least 500 N and an active ingredient release of at least 75% after 45 minutes, measured according to Pharm. Eur. in the paddle mixer with a sinker in a 600 ml aqueous buffer solution with a pH value of 1.2 at 37ºC and 75 revolutions per minute.