In Vivo Individualized Systemic Immunotherapeutic Method and Device

摘要

The invention provides an in vivo individualized systemic immunotherapeutic method and device. The method includes, in a non-sequential manner: (1) increasing release amount of tumor antigens at a tumor site; (2) at the tumor site, increasing level of proteins capable of adhering to and/or wrapping the tumor antigens; (3) at the tumor site, increasing level of dedicated antigen-presenting cells involved in immunity, and establishing, between the dedicated antigen-presenting cells and immune effector cells, a close connection capable of activating the immune effector cells; and (4) at the tumor site, increasing level and improving function of the immune effector cells. The steps (1)-(4) each reaches a maximum value at a respective time which overlaps with each other maximally, as well as at a respective site which overlaps with each other maximally. The invention combines oncolytic therapy and immunotherapy, in individualized systemic immunotherapy, and provides significantly improved therapeutic effect.

主权项

1. An anti-tumor therapeutic method, which is an in vivo individualized systemic immunotherapeutic method, comprising, in a non-sequential manner, the steps of:
(1) increasing release amount of tumor antigens at a tumor site where treatment is required in a tumor patient; (2) at the tumor site, increasing level of proteins capable of adhering to and/or wrapping the tumor antigens; (3) at the tumor site, increasing level of dedicated antigen-presenting cells involved in immunity, and establishing, between the dedicated antigen-presenting cells and immune effector cells, a connection capable of activating the immune effector cells; and (4) at the tumor site, increasing level of the immune effector cells and improving function thereof, thus establishing a connection between the immune effector cells and target cells, resulting in killing of the target cells; wherein the release amount of the tumor antigens in step (1), the level of the proteins capable of adhering to and/or wrapping the tumor antigens in step (2), the level of the dedicated antigen-presenting cells involved in immunity and the connection between the dedicated antigen-presenting cells and the immune effector cells in step (3), and the level and function of the immune effector cells in step (4) each reaches a maximum value at a respective time which overlaps with each other maximally, as well as at a respective site which overlaps with each other maximally.