Device and method for perfusing porous biomaterials with biological liquids

摘要

A device for perfusing porous biomaterials with biological liquids includes a tubular body with an axial cavity defining a perfusion chamber for containing a porous biocompatible material, a connector at a distal end of the tubular body for receiving a perfusion liquid, a plunger having a distal end slidably movable in the cavity to withdraw air from the biomaterial, a vent for releasing the air withdrawn from the biomaterial and contained in the chamber, and a filter permitting selective passage of the air contained in the chamber toward the vent, while preventing leakage of the liquid to the outside. An air collector communicates with the chamber and the vent, and a control unit is associated with the plunger and designed to be actuated by the user to control the air flow from the air collector to the vent.;A method of perfusing porous biomaterials with biological liquids.

主权项

1. A device for perfusing porous biomaterials with biological liquids, comprising:
a tubular body (2) with an axial cavity (3) defining a perfusion chamber (4) for containing a porous biomaterial (P); a connector (8) located at a distal end (7) of said tubular body (2) for introducing a perfusion liquid (L) therein; a plunger (11) having a distal end (12) slidably movable in said cavity (3) to withdraw air from the biomaterial (P) to be perfused; a vent (18) for releasing the air withdrawn from the biomaterial (P) and contained in said chamber (4) to an outside; a filter (29) for permitting selective passage of the air contained in said chamber (4) toward said vent (18), while preventing leakage of the liquid (L) to the outside; and an air collector (31), which communicates with said chamber (4) and said vent (18), a control unit (33) being associated with said plunger (11) and designed to be actuated by a user to control air flow from said collector (31) to said vent (18).