摘要 |
Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R1a, R1b, R1c, R2, R3, R4 and R are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient. |
申请人 |
F. HOFFMANN-LA ROCHE AG;GENENTECH, INC. |
发明人 |
CHENG, Yun-Xing;GOODACRE, Simon Charles;LI, Wei;RAY, Nicholas Charles;ZAK, Mark Edward |