Injectable aqueous ophthalmic composition and method of use therefor

摘要

The present invention is directed to the provision of an ophthalmic composition suitable for intravitreal injection. The composition includes an amount of complexing agent that reacts with one or more endogenous components (e.g., hyaluronic acid) in the eye to form a mass of enhanced viscosity. This mass can aid in creating a desirable release profile of therapeutic agent.

主权项

1. An injectable ophthalmic composition, comprising:
a therapeutic antibody; complexing agent in the composition at a concentration that is at least 0.01 w/v % but no greater than 10 w/v % of the composition wherein, upon injection into a vitreous humor of an eye of a human, the complexing agent forms a complex with endogenous hyaluronic acid, collagen or both to form a mass of enhanced viscosity within the vitreous humor and wherein the complexing agent is a positively charged galactomannan polymer, and water; wherein the mass of enhanced viscosity breaks down in the vitreous humor to release the antibody and/or the antibody diffuses out of the mass of enhanced viscosity over an extended period of time of at least 8 hours and wherein, upon formation, the mass of enhanced viscosity has a viscosity greater than the viscosity of the injectable composition at the time of injection and wherein the composition is contained within a syringe, the syringe having a needle suitable for intravitreal injection.