| 摘要 |
Hydroxy- and oxo-substituted alpha -benzylidenylcycloalkanes having the formula: <IMAGE> Z1, Z2 and Z3 each denotes a methoxy group or Z1 or Z2 and Z3 together denote a methylenedioxy group, and Z3 is a hydrogen atom or chlorine atom, one of the symbols R1 and R2 denotes a hydrogen atom and the other denotes a hydroxyl group or, together the two denote an oxygen atom; R3 denotes a hydrogen atom or a methyl group; R4 denotes a hydrogen atom, a methyl group or an aminomethyl group, the amino group being a dimethylamino, diethylamino, morpholino, 4-methyl-piperazino or piperidino radical; or R3 and R4 together denote a piperonylidene group; R5 denotes a hydrogen atom or a methyl group, and A forms, with the carbon atoms to which it is attached, a cyclopentane, cyclohexane, indane, tetrahydronaphthalene, perhydronaphthalene or piperidine structure and the pharmaceutically acceptable addition salts of the compounds containing an amino group. The compounds have pharmacological activity on the central nervous system. |
