SUBSTITUTED HYDROXY-ALKOXYPHOSPHINYL OXY-TRIALKYLAMINIUM HYDROXIDE INNER SALT OXIDES PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS

摘要

Compounds of formula I wherein R represents hydrogen, C14-18 - alkyl or CH2OR2 CH2CH2OR2, wherein R2 represents C14-18alkyl each R1 represents independently C1-3 alkyl m is l or 2 n is an integer from 2 to 8 and R4 and R5 together with the adjacent carbon atom represent wherein R3 represents alkyl, alkenyl, alkynyl, alkoxy, alkenoxy or alkynoxy each containing l2 to 24 carbon atoms whereby when R4 and R5 together with the adjacent carbon represent (i) ring e) R is H and (ii) other than ring e) R is other than H which exhibit pharmaceutical in particular anti-tumor activity.