发明名称 |
Method for preparing hylan and novel hylan product. |
摘要 |
<p>Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16 DEG C at very high pH, e.g. 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.</p> |
申请公布号 |
EP0320164(A2) |
申请公布日期 |
1989.06.14 |
申请号 |
EP19880311301 |
申请日期 |
1988.11.29 |
申请人 |
BIOMATRIX, INC. |
发明人 |
BALAZS, ENDRE A.;LESHCHINER, ADOLF;LESHCHINER, ADELYA;LARSEN, NANCY E.;BAND, PHILIP |
分类号 |
A61K8/72;A61K8/00;A61K8/73;A61K8/96;A61K31/715;A61K35/12;A61P17/00;A61P27/02;A61Q19/00;C08B37/08 |
主分类号 |
A61K8/72 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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