Tumor necrosis factor receptors on microorganisms

摘要

Cytokine receptors for tumor necrosis factor alpha which are found on microorganisms may, if bound with exogenous TNF alpha , enhance the response of natural killer cells activated by the microorganisms, or increase TNF alpha production by peripheral blood lymphocytes treated with the microorganisms. Microorganisms with receptor-bound exogenous TNF alpha have enhanced cellular invasion ability which may change the immune response thereto. Clinical and pharmaceutical applications of these discoveries including vaccines with increased efficacy are provided.