发明名称 |
Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses. |
摘要 |
Compounds of formula (I): <CHEM> [wherein: R<1> is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R<2> is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R<3> is carboxy or a group of formula -CONHSO2 R<4> wherein R<4> is alkyl]; and pharmaceutically acceptable salts and esters thereof have valuable 5 alpha -reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5 alpha -dihydro-testosterone. |
申请公布号 |
EP0567271(A3) |
申请公布日期 |
1994.11.23 |
申请号 |
EP19930302937 |
申请日期 |
1993.04.15 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
KOJIMA, KOICHI;KURATA, HITOSHI;ISHIBASHI, KOKI;HAMADA, TAKAKAZU;HORIKOSHI, HIROYOSHI |
分类号 |
C07J1/00;A61K;A61K31/56;A61K31/568;A61K31/575;A61P5/00;A61P13/02;A61P15/00;C07J;C07J41/00;C07J43/00 |
主分类号 |
C07J1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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