LIPOSOMAL BUPIVACAINE COMPOSITIONS PREPARED USING AN AMMONIUM SULFATE GRADIENT

摘要

Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprisin g "GMV" (giant multivesicular) liposomes and methods for their preparation. Th e liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.