发明名称 |
Method for assessing risk for cardiac dysrhythmia in a human subject |
摘要 |
The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a patient is obtained and the DNA or proteins of the sample isolated. From the DNA and protein isolates the sequence of the KCNJ2 gene or the Kir2.1 polypeptide can be obtained. The KCNJ2 gene or the Kir2.1 can be screened for alteration as compared to the wile-type sequence. An alteration in a copy of the KCNJ2 gene or a Kir2.1 polypeptide indicates that the patient has a high risk for developing a cardiac dysrhythmia and can be diagnosed with Andersen's Syndrome. The invention also related to isolated nucleic acid molecules with one or more alterations as compared to the wild-type sequence. |
申请公布号 |
AU2002258922(A1) |
申请公布日期 |
2002.11.05 |
申请号 |
AU20020258922 |
申请日期 |
2002.04.22 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
YING-HUI FU;LOUIS PTACEK |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;C07H21/04;C07H21/02;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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