| 摘要 |
A porous beta-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 mum, preferably 50-125 mum. The porous beta-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous beta-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous beta-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous beta-TCP material and inducing bone formation are also provided.
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