| 摘要 |
Oximes of 3,4-dimethoxyphenylpyruvic acid, lower alkyl esters, and their salts. These compounds can be produced by reacting a 3,4-dimethoxybenzylmalonic acid, di- (lower alkyl) ester with a lower alkyl nitrite in the presence of a base. The oximes are then converted by reductive acetylation, selective hydrolysis of the lower alkyl ester group, and acidification to N-acetyl-3-(3,4-dimethoxyphenyl)alanine. The latter compound is converted to 3-(3,4-dimethoxyphenyl)-L-alanine by the enzymatic action of an acylase and then to 3-(3,4-dihydroxyphenyl)-L-alanine by cleavage of the ether groups.
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