| 摘要 |
<p>Relaxin (RLX), a peptide hormone of the insulin family, has been found to produce impressive effects on the walls of blood vessels, on the blood clotting and on blood lipids and electrolytes, "per se," and through the stimulation of the synthesis and release of the two powerful substances: Nitric Oxide (NO) and Atrial Natriuretic Peptide (ANP). Experimental studies have shown that administration of RLX increases the blood flow and produces dilation of arteries, influences blood clotting and fibrinolysis and reduces blood lipids. RLX also induces reduction of blood osmolarity and sodium concentration. At the same time, through NO RLX inhibits release of histamine from mastocells. Therefore RLX is proposed as a therapeutic agent to be used in arteriosclerosis and vascular diseases, ischaemia and thrombosis, hypertension and pregnancy's gestosis. Finally, RLX can also be adopted in other diseases by NO as allergic and inflammatory disorders or by ANP as disfunctions in fluid and electrolytes balance.</p> |
