| 摘要 |
PURPOSE:To efficiently obtain a steroid as a synthetic intermediate for adrenocortical hormones in high yield in a small number of steps, by reacting a steroid having a specific partial structure with a silicon hydride compound in the presence of a rhodium catalyst, etc. CONSTITUTION:A steroid having a partial structure expressed by formula I (R<1> is alkyl), preferably 3beta-hydroxypregna-5,16-dien-2-one, pregna-4,16-dien-3,20- one or pregna-4,16-diene-3,11,20-trione, is reacted with a silicon hydride compound expressed by the formula HSiR<2>R<3>R<4> (R<2>-R<4> are alkyl), preferably triethylsilane or tripropylsilane, in a molar amount of preferably 1.1-1.3 times based on the steroid in the presence of a rhodium compound, preferably triphenylphosphinerhodium chloride, or nickel compound, e.g. nickel cyclooctadiene complex, in a catalytic amount to afford the aimed compound having the partial structure expressed by formula II.
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