发明名称 |
2-Substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases. |
摘要 |
<p>Disclosed herein are a novel 2-substituted adenosine derivative having the following formula [I] <CHEM> wherein R represents a hydrogen atom or a hydroxyl group, m is an integer of 2 to 7, n is 0 or an integer of 1 to 3, and R<1>, R<2> and R<3>, which may be the same or different, each independently represent a hydrogen atom, a hydroxy protective group or a phosphoric acid residue, and salts thereof. The above compounds are excellent in a circulation ameliorating effect such as a vasodepressor activity, and have high selectivity for A2 receptors, but cause less undesirable side effects such as a suppressive effect on the heart. They are therefore effective when used in pharmaceutical compositions for circulatory diseases.</p> |
申请公布号 |
EP0488336(A1) |
申请公布日期 |
1992.06.03 |
申请号 |
EP19910120461 |
申请日期 |
1991.11.29 |
申请人 |
YAMASA SHOYU KABUSHIKI KAISHA |
发明人 |
MIYASHITA, TAKANORI;ABIRU, TOICHI;WATANABE, YOKO;YAMAGUCHI, TOYOFUMI;MATSUDA, AKIRA, 10-501, MINAMI SHINKAWA |
分类号 |
C07H19/16 |
主分类号 |
C07H19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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