| 摘要 |
PCT No. PCT/GB94/01934 Sec. 371 Date Mar. 12, 1996 Sec. 102(e) Date Mar. 12, 1996 PCT Filed Sep. 6, 1994 PCT Pub. No. WO95/07904 PCT Pub. Date Mar. 23, 1995A class of imidazolone and oxazolone derivatives of Structure I, <IMAGE> (I) wherein X represents oxygen or N-R1; Q represents a substituted five-, six- or seven-membered monocyclic heteroaliphatic ring which contains one nitrogen atom as the sole heteroatom and is linked to the imidazolone or oxazolone ring via a carbon atom; R1 represents hydrogen or C1-6 alkyl; and one of R2 and R3 represents hydrogen or C1-6 alkyl and the other of R2 and R3 represents cycloalkyl or a group of formula (i), (ii) or (iii): <IMAGE> (i) <IMAGE> (ii) <IMAGE> (iii) in which Z represents oxygen, sulphur or NH; R4, R5 and R6 independently represent hydrogen, a hydrocarbon group or a heterocyclic group wherein the hydrocarbon group and heterocyclic group are as defined in the specification; or a pharmaceutically acceptable salt or prodrug thereof, which are ligands for dopamine receptor subtypes within the brain and are therefore of use in the treatment and/or prevention of disorders of the dopamine system, such as schizophrenia. |
