| 发明名称 |
IMPROVED RECOMBINANT HEPATITIS B SURFACE ANTIGEN |
| 摘要 |
<p>The present invention provides an improved rHBsAg that exhibits a higher antigenicity and immunogenicity than that previously known in the art. A method of making the improved rHBsAg is also provided. The improved HBsAg is used to provide vaccines with lower amounts of active ingredient, vaccines with higher immunogenicity and combination vaccines which produce and protective immunization against infection by hepatitis B virus and other infectious agents.</p> |
| 申请公布号 |
CA2355680(A1) |
申请公布日期 |
2000.06.29 |
| 申请号 |
CA19992355680 |
申请日期 |
1999.12.22 |
| 申请人 |
MERCK & CO. |
发明人 |
ZHAO, QINJIAN;SITRIN, ROBERT;GIMINEZ, JUAN;GERVAIS, DAVID P.;ABRAHAM, DICKY G. |
| 分类号 |
C12N15/09;A61K39/00;A61K39/05;A61K39/08;A61K39/09;A61K39/095;A61K39/10;A61K39/13;A61K39/25;A61K39/29;A61K39/295;A61P31/12;C07K14/02;C12P21/02;(IPC1-7):A61K39/00;C07K14/00;A61K45/00 |
主分类号 |
C12N15/09 |
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