| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for forming a micro-prilled poloxamer used specially in the pharmaceutical manufacturing industry as a dispersant or solubilizer and a vehicle presenting sustained release properties. <P>SOLUTION: The method for forming a micro-prilled poloxamer comprises using spraying gas at a pressure higher than ordinary pressure, a spraying nozzle at high spraying gas temperature and a high feed temperature for reducing poloxamer viscosity, and optionally, sieving after forming prills in a prilling column. The poloxamer prills are specially used in pharmaceutical preparations, being spherical with a nominal average size of preferably 106 μm or less. This method is highly cost-effective, being rapid in preparation. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
