摘要 |
<p>The invention relates to compounds of general formula (I): in which X<sub>1</sub> is a hydrogen or halogen atom or a (C<sub>1</sub>-C<sub>6</sub>)-alkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl-(C<sub>1</sub>-C<sub>3 </sub>)-alkylene, (C<sub>1</sub>-C<sub>6</sub>)-fluoroalkyl, cyano, C(O)NR<sub>1</sub>R<sub>2</sub>, nitro, (C<sub>1</sub>-C<sub>6</sub>)-thioalkyl, -S(O)-(C<sub>1</sub>-C<sub>6</sub>)-alkyl, -S(O)<sub>2</sub>-(C<sub>1</sub>-C<sub>6</sub>)-alkyl, SO<sub>2</sub>NR<sub>1</sub>R<sub>2,</sub> aryl-(C<sub>1</sub>-C<sub>6</sub>)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; X<sub>2</sub> is a hydrogen or halogen atom or a (C<sub>1</sub>-C<sub>6</sub>)-alkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl-(C<sub>1</sub>-C<sub>3 </sub>)-alkylene, (C<sub>1</sub>-C<sub>6</sub>)-fluoroalkyl, (C<sub>1</sub>-C<sub>6</sub>)-alkoxyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl-(C<sub>1</sub>-C<sub>6 </sub>)-alkylene-O-, (C<sub>1</sub>-C<sub>6</sub>)-fluoroalkoxyl, cyano, C(O)NR<sub>1</sub>R<sub>2</sub>, (C<sub>1</sub>-C<sub>6</sub>)-thioalkyl, -S(O)-(C<sub>1</sub>-C<sub>6</sub>)-alkyl, -S(O)<sub>2</sub>-(C<sub>1</sub>-C<sub>6</sub>)-alkyl, SO<sub>2</sub>NR<sub>1</sub>R<sub>2</sub>, aryl-(C<sub>1</sub>-C<sub>6</sub>)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; X<sub>3</sub> and X<sub>4</sub> are, independently of one another, a hydrogen or halogen atom or a (C<sub>1</sub>-C<sub>6</sub>)-alkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl-(C<sub>1</sub>-C<sub>3 </sub>)-alkylene, (C<sub>1</sub>-C<sub>6</sub>)-fluoroalkyl, (C<sub>1</sub>-C<sub>6</sub>)-alkoxyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl-(C<sub>1</sub>-C<sub>6 </sub>)-alkylene-O-, (C<sub>1</sub>-C<sub>6</sub>)-fluoroalkoxyl, cyano, C(O)NR<sub>1</sub>R<sub>2</sub>, nitro, NR<sub>1</sub>R<sub>2</sub>, (C<sub>1</sub>-C<sub>6</sub>)-thioalkyl, -S(O)-(C<sub>1</sub>-C<sub>6</sub>)-alkyl, -S(O)<sub>2</sub>-(C<sub>1</sub>-C<sub>6</sub>)-alkyl, SO<sub>2</sub>NR<sub>1</sub>R<sub>2</sub>, NR<sub>3</sub>COR<sub>4</sub>, NR<sub>3</sub>SO<sub>2</sub>R<sub>5</sub>, aryl-(C<sub>1</sub>-C<sub>6</sub>)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; Z<sub>1</sub>, Z<sub>2</sub>, Z<sub>3</sub> and Z<sub>4</sub> are, independently of one another, a nitrogen atom or a C(R<sub>6</sub>) group; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; Ra and Rb are, independently of one another, a hydrogen atom or a (C<sub>1</sub>-C<sub>6</sub>)<sub>-</sub>alkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl-(C<sub>1</sub>-C<sub>3 </sub>)-alkylene, (C<sub>1</sub>-C<sub>6</sub>)-fluoroalkyl, hydroxyl, (C<sub>1</sub>-C<sub>6</sub>)-alkoxyl, (C<sub>3</sub>-C<sub>7</sub>)-cycloalkyl-(C<sub>1</sub>-C<sub>6 </sub>)-alkylene-O-, (C<sub>1</sub>-C<sub>6</sub>)-fluoroalkoxyl, aryl or heteroaryl group, wherein Ra and Rb may be optionally substituted; in the form of a base or an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for the preparation thereof and therapeutic use.</p> |