A PROCESS FOR MAKING N-(4-FLUOROPHENYL)-N-(1-METHYLETHYL)-2-[(5-TRIFLUOROMETHYL)-1,3,4-THIADIAZOL-2-YL)OXY]ACETAMIDE USING AN APROTIC, AROMATIC SOLVENT

摘要

The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-¢(5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy!acetamide in an aprotic, aromatic solvent. The process includes the steps of: (a) reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole with N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide in the presence of an aprotic, aromatic solvent to form an aqueous phase and an organic phase; (b) acidifying the phases, (c) separating the phases; and (d) recovering the N-(4-fluorophenyl)-N-(1-methylethyl)-2-¢(5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy!acetamide from the organic phase.