| 摘要 |
<p>2-Phenyl 5-methyl 6-alkyl 1,2,6-thiadiazine-3(2H)-one 1,1-dioxide and its 4-substd. derivs. of formula (I), in which R1 is hydrogen or halogen and R2 is hydrogen or alkyl, for use as analgesic, anti-pyretic and anti-inflammatory agents, are made by (a) condensn. of phenyl sulphamide with aceto-acetic ester or its diketene deriv., in alkaline medium; (b) cyclising the prod. by acidification; (c) alkylation with an alkyl halide in alkaline medium; and (d) treatment with a halogenating agent in chloroform at ambient temp..</p> |
