发明名称 |
Verfahren zur Herstellung von L-Phenylephrinhydrochlorid |
摘要 |
The invention relates to an improved method for the industrial-scale production of L-phenylephrine hydrochloride 3 by asymmetric hydrogenation as key step and a special series of subsequent steps. According to the invention [Rh(COD)Cl]2 is used as catalyst and a chiral, bidentate phosphine ligand such as (2R, 4R)-4-(dicyclohexylphospino)-2-(diphenylphosphino-methyl)-N-methyl-ami nocarbonyl-pyrrolidine is used as catalyst system.
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申请公布号 |
DE19902229(A1) |
申请公布日期 |
2000.08.03 |
申请号 |
DE1999102229 |
申请日期 |
1999.01.21 |
申请人 |
BOEHRINGER INGELHEIM PHARMA KG |
发明人 |
KLINGLER, FRANZ DIETRICH;WOLTER, LIENHARD;DIETRICH, WOLFGANG |
分类号 |
C07C213/08;C07B53/00;C07B61/00;C07C213/00;C07C215/60;(IPC1-7):C07C215/60;B01J31/24;C07F15/00 |
主分类号 |
C07C213/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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