| 发明名称 |
3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by VLA-4 |
| 摘要 |
Compounds of the formula which inhibit leukocyte adhesion mediated by interaction of the alpha 4 beta 1 integrin (VLA-4) with its counterreceptor VCAM-1, and their use for the treatment of inflammatory and autoimmune diseases.
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| 申请公布号 |
US6166050(A) |
申请公布日期 |
2000.12.26 |
| 申请号 |
US19990458852 |
申请日期 |
1999.12.10 |
| 申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
LOMBARDO, LOUIS J.;SABALSKI, JOAN |
| 分类号 |
C07C229/36;C07C233/87;C07C271/44;C07D209/14;C07D211/62;C07D213/38;C07D213/81;C07D213/82;C07D233/54;C07D295/135;C07D295/185;C07D295/205;(IPC1-7):C07D213/02;A61K31/44 |
主分类号 |
C07C229/36 |
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