| 摘要 |
Disclosed herein are methods of diagnosing and treating metastatic breast cancer. The methods entail detecting an expression level of FOXC1 in a population of breast cancer tumor cells from the subject, detecting an expression level of FOXA1 in the population of breast cancer tumor cells, and diagnosing a patient as having metastatic breast cancer if the expression ratio of FOXC1/FOXA1 in the population of breast cancer tumor cells is elevated as compared to a control. The methods also entail administering a treatment for metastatic breast cancer if the expression ratio of FOXC1/FOXA1 in the population of breast cancer tumor cells is elevated as compared to a control. Methods of predicting overall survival and early (pre-symptomatic) diagnosis of early breast cancer metastasis are also provided herein. |
