NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF

摘要

Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.;

主权项

1. A compound, having the formula: wherein R1 independently is:a primary or tertiary amine, OR11, or an amino acid, and wherein the R11 independently is hydrogen, alkyl, alkene, alkyne; and
R2, R3, R4, R5, R6, R7, R8, R9, and R10 are each independently is hydrogen, alkyl, alkene, alkyne, halogen, alkoxy with or without more or more carbon-carbon double or triple bonds, cyano group, or nitrile group.