3-AMIDO-1,2-BENZOISOXAZOLE DERIVATIVE, SALT THEREOF, METHOD OF PREPARING THE SAME AND USAGE THEREOF

摘要

PURPOSE: Provided is a 3-amido-1,2-benzoisoxazole derivative or a pharmaceutically acceptable addition salt thereof which has improved bioavailability by increasing the aqueous solubility, shows excellent antagonistic effect on an LTB-4 receptor and prevents and/or treats osteoporosis. CONSTITUTION: The 3-amido-1,2-benzoisoxazole derivative of the formula(1) is prepared by introducing an amino acid residue into the amine group of 3-amido-1,2-benzoisoxazole. In the formula(1), R1 is hydrogen, a hydroxyl group, a linear or branched chain alkyl group with C1-C6, a benzyl group or a 2-methylthioethyl group; R2 is hydrogen or -COC(NH2)R3, and R3 is hydrogen, a hydroxyl group, a linear or branched chain alkyl group with C1-C6, a benzyl group, or a 2-methylthioethyl group.