UREA DERIVATIVES AS 5-HT ANTAGONISTS

摘要

A compound of formula (I) wherein R<1> is cyano, thiocarbamoyl, a group of formula (a) in which R<4> is hydrogen, lower alkyl which may have optionally substituted aryl, acyl, optionally substituted aryl, lower alkylthio or 1-lower alkylindolyl, A<1> is lower alkylene, and m and n are each 0 or 1, a group of the formula -A<2>-R<5> in which R<5> is morpholino, piperidino, 4-arylpiperazin-1-yl, phthalimido, 1,2,3,4-tetrahydroquinolin-1-yl, 1,2,3,4-tetrahydroisoquinolin-2-yl or imidazol-1-yl, and A<2> is lower alkylene, or a group of formula (b) in which R<6> and R<7> are each hydrogen, optionally substituted aryl, acyl, pyridyl(lower)alkyl, thienyl(lower)alkyl, 3,4-dihydroisoquinolinyl, (lower alkylimino) (optionally substituted aryl) methyl or lower alkyl which may have optionally substituted aryl, and A<3> is lower alkylene, and R<2> is hydrogen; or R<1> and R<2> are linked together to form (1), (2), or (3), in which R<8> is amino or acylamino, and R<9> is hydrogen, acyl or lower alkyl which may have optionally substituted aryl, and R<3> is 1-lower alkylindolyl, benzofuranyl, dihydrobenzofuranyl, or optionally substituted aryl, and a pharmaceutically acceptable salt thereof, which is useful as a medicament for prophylactic and therapeutic treatment of 5-HT mediated diseases.